Blood-BrainBarrier相关论文
Neurovascular dysfunction, as an integral part of Alzheimer\'s disease, may have an important influence on the onset a......
Transcranial focused ultrasound stimulation reduces vasogenic edema after middle cerebral artery occ
Blood-brain barrier (BBB) disruption underlies the vasogenic edema and neuronal cell death induced by acute ischemic str......
Urolithin A alleviates blood-brain barrier disruption and attenuates neuronal apoptosis following tr
Urolithin A (UA) is a natural metabolite produced from polyphenolics in foods such as pomegranates,berries,and nuts.UA i......
A neurovascular unit-on-a-chip: culture and differentiation of human neural stem cells in a three-di
Biological studies typically rely on a simple monolayer cell culture, which does not reflect the complex functional char......
Neuroinflammation is a major pathophysiological factor that results in the development of brain injury after cerebral is......
In 2001, the concept of the neurovascular unit was introduced at the Stroke Progress Review Group meeting. The neurovasc......
Myeloperoxidase is an important inflammatory factor in the myeloid system, primarily expressed in neutrophils and microg......
Alzheimer\'s disease is a neurodegenerative condition leading to atrophy of the brain and robbing nearly 5.8 million i......
Glucose is the essential and almost exclusive metabolic fuel for the brain. Ischemic stroke caused by a blockage in one ......
In Alzheimer\'s disease and ischemic stroke, intranasal insulin can act as a neuroprotective agent. However, whether i......
The mouse model of multiple cerebral infarctions, established by injecting fluorescent microspheres into the common caro......
Circular RNAs (circRNAs) are a new and large group of non-coding RNA molecules that are abundantly expressed in the cent......
Exacerbated VEGF up-regulation accompanies diabetes-aggravated hemorrhage in mice after experimental
Reperfusion therapy is the preferred treatment for ischemic stroke, but is hindered by its short treatment window, espec......
Dexmedetomidine maintains blood-brain barrier integrity by inhibiting Drp1-related endothelial mitoc
Stroke is the second leading cause of death and long-term disability worldwide,which lacks effective treatment.Periopera......
Qualitative detection of ginsenosides in brain tissues after oral administration of high-purity gins
Given the limited studies and conflicting findings,the transport character of ginsenosides crossing the blood-brain barr......
XingNaoJing injections protect against cerebral ischemia/reperfusion injury and alleviate blood-brai
The aim of this study was to explore the neuroprotective effect and mechanism of XingNaoJing injections (XNJ) on cerebra......
...
...
Fluoxetine is Neuroprotective in Early Brain Injury via its Anti-inflammatory and Anti-apoptotic Eff
Fluoxetine,an anti-depressant drug,has recently been shown to provide neuroprotection in central nervous system injury,b......
Development of Human in vitro Brain-blood Barrier Model from Induced Pluripotent Stem Cell-derived E
An in vitro blood-brain barrier (BBB) model is critical for enabling rapid screening of the BBB permeability of the drug......
Aloin is a small-molecule drug well known for its protective actions in various models of damage.Traumatic brain injury ......
...
Study on CT Perfusion Surface Permeability of Cerebral Hemorrhage in The Basal Ganglia Region in Sub
Objective To study alterations of permeability of surface(PS)in subacute stage intracerebral hemorrhage(ICH)patients wit......
Blood-brain barrier disruption in the brain of aged spontaneously hypertensive rats evaluated by dyn
Background and Purpose Evaluating of blood-brain barrier(BBB)disruption in the brain of elderlies with spontaneous hyper......
Prediction of Reperfusion-Associated Hemorrhagic Transformation Using Dynamic Contrast-Enhanced Imag
Background and Purpose: Reperfusion-associated hemorrhagic transformation(HT)is an important complication of recanalizat......
Acceleration of experimental cerebral malaria by aspirin via elevating the pro-inflammatory response
...
Objective: von Willebrand factor(VWF)has recently been demonstrated to promote inflammation processes.In the present stu......
Methylene Blue improves the disruption of blood brain barrier and attenuates astroglia activation af
Methylene blue(MB)was first synthesized in 1876 and has been used as treatment for malaria,methemoglobinemia,and cyanide......
Vulnerable vasculature and increased inflammation contribute to earlier death and higher mortality a
Type 1 diabetic patients are found to be more prone to cerebrovascular mortality from stroke in epidemiological studies,......
Normobaric hyperoxia slows BBB damage and expands the therapeutic time window for tPA treatment in c
Background and purpose: Prolonged ischemia causes blood-brain barrier(BBB)damage and increases the incidence of neurovas......
Background and purpose:Drug resistance in epilepsy is considered as a complicated and multifactorial problem.Insufficien......
A Novel Core-Shell Structural Phospholipid-Functionalized Mesoporous Silica Nanoparticles Modified w
In order to improve the drug loading coefficient and realize the targeting delivey of paclitaxel (PTX) to brain and glio......
Regulatory mechanisms of AQP-4 on blood-brain barrier damage after cerebral ischemia reperfusion inj
Aquaporin4 (AQP4), a waterchannel protein, is highly expressed in the brain, which is important elements in the formatio......
Bradykinin down-regulating the expression levels of ZO-1, occludin and disrupting actin cytoskeleton
Objective Tight junction (TJ) is an important structural and functional basis of maintaining blood-brain barrier (BBB) i......
Does Propofol suppress C6 glioma invasion in rats?Concentration effects and blood-brain barrier chan
...
Surgery-induced hippocampal angiotensin Ⅱ elevation causes blood-brain barrier disruption via MMP/TI
Reversible BBB disruption has been uniformly reported in several animal models of postoperative cognitive dysfunction (P......
Amyloid-β plaques and neurofibrillary tangles are the main neuropathological hallmarks in Alzheimers disease(AD),the mo......
Transportation of neuroprotective flavonoids, based on cell toxicity: a comparison using the blood-b
Aim: Comparative evaluations of the transmembrane transport of eight cerebrovascular protection flavonoids including pue......
Altered expression of matrix metalloproteinases and Glucose transporter-1 with PEMF-induced BBB perm
Purpose: Recent studies suggest that electromagnetic field exposure alters blood-brain barrier permeability, and the tra......
Effective vascular dementia therapy of calmodulin antagonist delivered by polysialic acid based mice
Vascular dementia (VaD) is regarded as the second most frequent type of dementia world-wide following Alzheimers disease......
A Novel Core-Shell Structural Phospholipid-Functionalized Mesoporous Silica Nanoparticles Modified w
In order to improve the drug loading coefficient and realize the tagerted delivey of paclitaxel (PTX) to brain glioma, a......
Neurotoxicity is one of the major potential side effects of colistintherapy.However,the mechanistic aspects of colistin-......
Isoastragaloside I suppresses LPS-induced blood-brain barrier disruption via activating Nrf2 pathway
...
Yes-associated protein(YAP)is a key transcriptional cofactor of the Hippo pathway,critical for the development of multip......
Scalp mechanical stimulation promotes moderate vasodilation and the permeability of blood-brain barr
OBJECTIVE Scalp mechanical stimulation,like combing,is one of the useful methods to keep brain health,which was historic......
Identification of Mfsd2A as a potential biomarker for blood-brain barrier disorders caused by Escher
...
Rapib and efficient crossing blood-brain barrier:Hydrophobic drug delivery system based on propionyl
A novel strategy of rapid transport across the blood-brain barrier(BBB)via phosphatidylethanolamine(POPE)-triggered rele......
The influence of pore insert on tight junctions between cerebral brain endothelial cells of adult ra
Objective: Blood-brain barrier(BBB)is the structural basis of the central nervous system to maintain a stable internal e......
Attenuated Blood-Brain Barrier Dysfunction by XQ-1H Following Ischemic Stroke in Hyperlipidemic Rats
Following ischemic stroke, blood-brain barrier (BBB) is disrupted and is further aggravated with the corresponding incid......
